The 28-year old Olympic champion has accused the IAAF of treating her like a human guinea pig, claiming the world athletics' governing body used her to experiment with testosterone-reducing drugs.
"The IAAF used me in the past as a human guinea pig to experiment with how the medication they required me to take would affect my testosterone levels," said Semenya in a statement.
Semenya is opposing in court the federation's new rules requiring women athletes with a condition known as hyperandrogenism to artificially lower their testosterone levels for them to be allowed to compete in races of between 400m and 1 mile but her appeal was dismissed by the Court of Arbitration for Sport (CAS) to halt the introduction of regulations to limit testosterone in females.
"Even though the hormonal drugs made me feel constantly sick, the IAAF now wants to enforce even stricter thresholds with unknown health consequences," Semenya said.
"I will not allow the IAAF to use me and my body again. But I am concerned that other female athletes will feel compelled to let the IAAF drug them and test the effectiveness and negative health effects of different hormonal drugs. This cannot be allowed to happen."
Switzerland Supreme court had last week temporarily suspended the new IAAF rules pending the hearing and determination of an appeal by Semenya.
But with the latest ruling, Semenya and other women with her conditions have lost as the court ruled that the rules were "discriminatory" but "necessary" to ensure fairness in women's athletics.
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